Authors: Claude Berenger Ngantchouko Ngalemo , Gisele Laurel Tchiengang Tchoua , Francois Nicaise Bony , Blondin Gatien Tsawo , Patrick Yamen Mbopi , Stephane Kevin Ndengue Langoul , Jean Michel Tekam , Pierre Rene Fotsing Kwetche

In Chemistry, Chemical Engineering

By Science Publishing Group

Erectile dysfunction has become for two decades, a real public health problem. Its prevalence is estimated at 322 million in 2025. Its management is based on the administration of phosphodiesterase inhibitors alone or in combination. Infections have been rarely mentioned although E coli, Staphylococcus aureus, Klebsiella pneumoniae or Serratia marcescens are recognized as factors of erectile dysfunction. The purpose of this study was to evaluate the phytochemical profile of the aqueous (AE) and hydroethanolic (HE) extracts of the fresh leaves of Gardenia aqualla and to determine their antibacterial potential on bacteria involved in male accessory gland infections. The aim of this study was to evaluate phytochemical profile of aqueous (AE) and hydroethanolic (HE) extracts of fresh leaves of Gardenia aqualla and to determine their antibacterial potential on bacteria involved in male accessory gland infections. Phytochemical profile highlighted the presence of alkaloids, polyphenols with concentrations of 434.5 ± 14.5 mgEq Tannic acid/g of dried extract greater than 249.5±18.3 mgEq Tannic acid/g of dried extract found in AE including flavonoids whose concentrations is 184.9 ± 6.3 μgEqRutin/g of dry extract in HE against 183.0±9.1 μgEqRutin/g of dried extract in AE. Antibacterial tests showed equivalence of activity on E coli and S aureus strains with MICs of 100 mg/mL and 50mg/mL respectively and only HE showed activity on Klebsiella pneumoniae and Serratia marcescens which had the lowest MIC 6.25 mg/mL.

Authors: Izzeldeen Daoud Mahmoud Shehadeh , Ahmad Mahmood Ahmad Kharabsha

In Social and Behavioral Sciences, Psychology

By Science Publishing Group

The current research seeks to explore and generate scientific indications about diagnosis, challenges and future suggestions from psychiatrists' point of view for the possibility of transmitting anxiety from parents to their children using the Grounded Theory. To achieve these goals, the researchers used the grounded theory approach as one of the qualitative research designs and analyzed the data collected from (11) specialized psychiatrists at the National Center for Psychiatry in the Hashemite Kingdom of Jordan through structured and semi-structured interviews. The results of interviews with psychiatrists revealed the presence of four developed categories or concepts, the first developed concept “scientific indicators for diagnosing the possibility of transmission of anxiety from the psychiatrist’s point of view,” the second developed concept “the challenges facing the psychiatrist in diagnosing the possibility of transmission of anxiety,” and the third developed concept. Solutions: future prospects for the psychiatrist to prevent the possibility of anxiety transmission” and finally, the fourth developed concept “important aspects of the psychiatrist’s focus on preventing the possibility of anxiety transmission.” From parents to their children and to prevent them in the future, and that this process is difficult due to the multiple sources of anxiety and their continuous interaction (environmental indicators, genetic indicators), and therefore it must face challenges, which need future follow-up, in order to reduce this possibility and prevent it in the future. The results of the current research, we need to pay attention to focusing on the prevention aspect by preparing for a comprehensive integrated plan in the system Health care for the Hashemite Kingdom of Jordan (considering the results of this current research) to prevent the transmission of anxiety in the future.

Authors: Mulyadi , Abdul Rozak , Dede Endang Mascita

In Education

By Science Publishing Group

This study aims to develop explanatory text e-module teaching materials based on local wisdom for SD/MI students. Background of the problem of this research (1) How is the design of explanatory text e-module teaching materials based on local wisdom for SD/MI students? (2) What are the results of implementing local wisdom-based explanatory text e-module teaching materials for SD/MI students? This research uses research and development methods (Research and Development) with the ADDIE (Analysis Design Development Implementation Evaluate) model. The steps of this research consist of needs analysis, designing teaching materials (e-modules), developing teaching materials (e-modules), product implementation (e-module teaching materials), and product evaluation (e-module teaching materials). The method of collecting data in this study was by collecting data from the results of expert validation questionnaires and student assessment questionnaires. Data acquisition was analyzed descriptively by using a Likert scale. The results of the validation test by material experts obtained a value of 3.1, the validation test by the mediating expert obtained a value of 3.56. The validation test by the Indonesian language teacher obtained a value of 3.13. The results of the implementation of e-module teaching materials at school obtained a positive response from students by obtaining a score of 3.3. The conclusions from this study are that the e-module teaching materials based on local wisdom for SD/MI students meet the criteria of being very suitable for use as teaching materials by students or teachers in the Indonesian subject of explanation text materials for SD/MI grade VI students.

Authors: Linda Darling-Hammond , Lisa Flook , Channa Cook-Harvey , Brigid Barron , David Osher

In Education

By NCBI Pubmed

This article draws out the implications for school and classroom practices of an emerging consensus about the science of learning and development, outlined in a recent synthesis of the research. Situating the review in a developmental systems framework, we synthesize evidence from the learning sciences and several branches of educational research regarding well-vetted strategies that support the kinds of relationships and learning opportunities needed to promote children’s well-being, healthy development, and transferable learning. In addition, we review research regarding practices that can help educators respond to individual variability, address adversity, and support resilience, such that schools can enable all children to find positive pathways to adulthood.

Authors: Heidi M. Levitt , Michael Bamberg , John W. Creswell , David M. Frost , Ruthellen Josselson , Carola Suárez-Orozco

In Other

By NCBI Pubmed

The American Psychological Association Publications and Communications Board Working Group on Journal Article Reporting Standards for Qualitative Research (JARS–Qual Working Group) was charged with examining the state of journal article reporting standards as they applied to qualitative research and with generating recommendations for standards that would be appropriate for a wide range of methods within the discipline of psychology. These standards describe what should be included in a research report to enable and facilitate the review process. This publication marks a historical moment—the first inclusion of qualitative research in APA Style, which is the basis of both the Publication Manual of the American Psychological Association (APA, 2010) and APA Style CENTRAL, an online program to support APA Style. In addition to the general JARS–Qual guidelines, the Working Group has developed standards for both qualitative meta-analysis and mixed methods research. The reporting standards were developed for psychological qualitative research but may hold utility for a broad range of social sciences. They honor a range of qualitative traditions, methods, and reporting styles. The Working Group was composed of a group of researchers with backgrounds in varying methods, research topics, and approaches to inquiry. In this article, they present these standards and their rationale, and they detail the ways that the standards differ from the quantitative research reporting standards. They describe how the standards can be used by authors in the process of writing qualitative research for submission as well as by reviewers and editors in the process of reviewing research.

Authors: Yingyue Zhou , Mari Tada , Zhangying Cai , Prabhakar S. Andhey , Amanda Swain , Kelly R. Miller , Susan Gilfillan , Maxim N. Artyomov , Masaki Takao , Akiyoshi Kakita , Marco Colonna

In Life Sciences, Nature

By NCBI Pubmed

The TREM2–DAP12 receptor complex sustains microglia functions. Heterozygous hypofunctional TREM2 variants impair microglia, accelerating late-onset Alzheimer’s disease. Homozygous inactivating variants of TREM2 or TYROBP-encoding DAP12 cause Nasu–Hakola disease (NHD), an early-onset dementia characterized by cerebral atrophy, myelin loss and gliosis. Mechanisms underpinning NHD are unknown. Here, single-nucleus RNA-sequencing analysis of brain specimens from DAP12-deficient NHD individuals revealed a unique microglia signature indicating heightened RUNX1, STAT3 and transforming growth factor-β signaling pathways that mediate repair responses to injuries. This profile correlated with a wound healing signature in astrocytes and impaired myelination in oligodendrocytes, while pericyte profiles indicated vascular abnormalities. Conversely, single-nuclei signatures in mice lacking DAP12 signaling reflected very mild microglial defects that did not recapitulate NHD. We envision that DAP12 signaling in microglia attenuates wound healing pathways that, if left unchecked, interfere with microglial physiological functions, causing pathology in human. The identification of a dysregulated NHD microglia signature sparks potential therapeutic strategies aimed at resetting microglia signaling pathways.

Authors: Andrew G. Soerens , Marco Künzli , Clare F. Quarnstrom , Milcah C. Scott , Lee Swanson , JJ. Locquiao , Hazem E. Ghoneim , Dietmar Zehn , Benjamin Youngblood , Vaiva Vezys , David Masopust

In Life Sciences, Nature

By NCBI Pubmed

Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans1,2,3. To provide immunity, transiently stimulated CD8+ T cells undergo unusually rapid bursts of numerous cell divisions, and then form quiescent long-lived memory cells that remain poised to reproliferate following subsequent immunological challenges. Here we addressed whether T cells are intrinsically constrained by chronological or cell-division limits. We activated mouse T cells in vivo using acute heterologous prime–boost–boost vaccinations4, transferred expanded cells to new mice, and then repeated this process iteratively. Over 10 years (greatly exceeding the mouse lifespan)5 and 51 successive immunizations, T cells remained competent to respond to vaccination. Cells required sufficient rest between stimulation events. Despite demonstrating the potential to expand the starting population at least 1040-fold, cells did not show loss of proliferation control and results were not due to contamination with young cells. Persistent stimulation by chronic infections or cancer can cause T cell proliferative senescence, functional exhaustion and death6. We found that although iterative acute stimulations also induced sustained expression and epigenetic remodelling of common exhaustion markers (including PD1, which is also known as PDCD1, and TOX) in the cells, they could still proliferate, execute antimicrobial functions and form quiescent memory cells. These observations provide a model to better understand memory cell differentiation, exhaustion, cancer and ageing, and show that functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan.

Authors: Marieke de Regt , Rogier Ooijevaar , Marcel Jonges , Matthijs R A Welkers , Alex Wagemakers

In Life Sciences

By NCBI Pubmed

A 26-year-old man reporting a 6-day history of fever, malaise, and a swollen cheek, was referred to our emergency room. The day before his attendance, he had been seen by his general practitioner and started on oral amoxicillin and clavulanic acid. However, his cheek continued to swell, and he developed a temperature of 39·4oC, prompting the referral.

Authors: Di Chen , Si Yu Tao , Tian Le Chen , Ying Yu Luo , Zhu Ling Guo

In Medicine and Health Sciences, Medicine, Public Health

By Science Publishing Group

Headache is a common nervous system symptom with complex causes, including neurogenic, odontogenic, vascular, infectious and so on. Headache is generally manifested as pain in the region above the skull, orbit and occipital bone. But sometimes it also involves pain in the oral and maxillofacial region, because the craniofacial region is closely adjacent to the oral anatomy. Some oral diseases, such as pulpitis, temporomandibular joint disorder syndrome, and oral mucosal disease, can not only cause pain at the primary site, but also show head and face pain. Therefore, headache is easily confused with some oral diseases in clinical diagnosis. A large number of clinical reports at home and abroad have analyzed the correlation between neurologic diseases and oral diseases. This paper attempts to analyze the internal relationship between the two from clinical manifestations, pathogenesis and other aspects, focusing on the discussion of headache caused by oral diseases, which is meaningful for stomatologists and neurologists, and is conducive to expanding the thinking of oral disease research and diagnosis and treatment.