Strategies and Challenges for the Next Generation of Antibody-Drug Conjugates
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Abstract
Antibody-drug conjugates (ADCs) have revolutionized the field of targeted cancer therapy by combining the specificity of monoclonal antibodies with the potency of cytotoxic drugs. ADCs have shown remarkable clinical success, leading to several FDA-approved therapies. However, the development of the next generation of ADCs presents new strategies and challenges that must be addressed to improve efficacy, safety, and therapeutic index. This article explores the innovative approaches taken to optimize ADC design, enhance tumor targeting, and overcome resistance mechanisms, while also discussing the challenges faced in the development of these promising therapeutics.
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