Authors: Nwoke Emmanuel Chukwuebuka , Ebenezer Obi Daniel , Oladapo Michael Olagbegi , Paul Olaiya Abiodun , Ahmed Mamuda Bello , Michael Avwerhota , Michael Olabode Tomori , Friday Iyobosa Igbinovia , Adebanke Adetutu Ogun , Folake Abiola Abiodun , Stellamaris Moronkeji , Esther Brodrick-Shehu

In Medicine and Health Sciences, Medicine, Public Health

By Science Publishing Group

The issue of COVID-19 vaccination is an important step in the control of the COVID-19 infection in the community. There have been different adopted strategies in the control of the infection and the best public intervention has been getting vaccinated for now. The most likely solution to ending the current pandemic remains through achieving a better community reach, and the frank acceptance of the availed WHO-approved COVID-19 vaccine in communities. In this study, the reason for the COVID-19 vaccine uptake was evaluated across 3 geopolitical zones in Nigeria with differential political affiliation. This study utilized a qualitative sample collection methodology to qualify the prevalence of different views on COVID-19 vaccine acceptability, access, and political trust. The data was gathered utilizing pre-tested in-depth interviews, which were transcribed and analyzed thematically through the transcripts obtained from the open-ended key informant interviews. The findings from the qualitative studies indicated that the fear of the side effects, apathy/lack of interest, scarce logistics, people’s opinion, and self-denial were more of the pertinent issue around the poor COVID-19 vaccine uptake among the respondents. Government needs to ensure that health interventions rolled are adequately accessible to the targeted people and should consider the community culture while rolling out health interventions.

Authors: Michael Böhm , Jan-Christian Reil , Prakash Deedwania , Jae B. Kim , Jeffrey S. Borer

In Medicine and Health Sciences, Medicine, Public Health

By NCBI Pubmed

Resting heart rate is central to cardiac output and is influenced by changes occurring in numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence suggests that it is also an important marker of outcome in cardiovascular disease, including heart failure. Beta-blockers improve outcomes in heart failure; however, they have effects outside reducing heart rate. Ivabradine has demonstrated efficacy in reducing rehospitalizations and mortality in heart failure and in improving exercise tolerance and reducing angina attacks in patients with coronary artery disease, whereas selective heart rate reduction may also prove to be beneficial in therapeutic areas outside those in which ivabradine has already demonstrated clinical efficacy. This review provides an update on the associations between heart rate and cardiovascular outcomes in various conditions, the experimental effects of heart rate reduction with ivabradine, and the potential new indications in cardiovascular disease.

Authors: Queenie Fernandes , Varghese Philipose Inchakalody , Maysaloun Merhi , Sarra Mestiri , Nassiba Taib , Dina Moustafa Abo El-Ella , Takwa Bedhiafi , Afsheen Raza , Lobna Al-Zaidan , Mona O Mohsen , Mariam Ali Yousuf Al-Nesf , Ali Ait Hssain , Hadi Mohamad Yassine , Martin F Bachmann , Shahab Uddin , Said Dermime

In Life Sciences, Medicine and Health Sciences, Medicine, Internal Medicine

By NCBI Pubmed

The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing rapid and sensitive diagnostic technologies is now more challenging due to emerging variants and varying symptoms exhibited among the infected individuals. In addition to this, vaccines remain the major mainstay of prevention and protection against infection. Novel vaccines and drugs are constantly being developed to unleash an immune response for the robust targeting of SARS-CoV-2 and its associated variants. In this review, we provide an updated perspective on the current challenges posed by the emergence of novel SARS-CoV-2 mutants/variants and the evolution of diagnostic techniques to enable their detection. In addition, we also discuss the development, formulation, working mechanisms, advantages, and drawbacks of some of the most used vaccines/therapeutic drugs and their subsequent immunological impact.

Authors: Di Chen , Si Yu Tao , Tian Le Chen , Ying Yu Luo , Zhu Ling Guo

In Medicine and Health Sciences, Medicine, Public Health

By Science Publishing Group

Headache is a common nervous system symptom with complex causes, including neurogenic, odontogenic, vascular, infectious and so on. Headache is generally manifested as pain in the region above the skull, orbit and occipital bone. But sometimes it also involves pain in the oral and maxillofacial region, because the craniofacial region is closely adjacent to the oral anatomy. Some oral diseases, such as pulpitis, temporomandibular joint disorder syndrome, and oral mucosal disease, can not only cause pain at the primary site, but also show head and face pain. Therefore, headache is easily confused with some oral diseases in clinical diagnosis. A large number of clinical reports at home and abroad have analyzed the correlation between neurologic diseases and oral diseases. This paper attempts to analyze the internal relationship between the two from clinical manifestations, pathogenesis and other aspects, focusing on the discussion of headache caused by oral diseases, which is meaningful for stomatologists and neurologists, and is conducive to expanding the thinking of oral disease research and diagnosis and treatment.